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Publication details
Ultrashort Bradycardic Effect of Newly Synthetized Compounds
Authors | |
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Year of publication | 2006 |
Type | Article in Periodical |
Magazine / Source | Acta Veterinaria Brunensis |
MU Faculty or unit | |
Citation | |
Field | Pharmacology and pharmaceutical chemistry |
Keywords | bradycardic effect;membrane currents;esmolol;rat;heart rate |
Description | Changes in heart rate induced by four different doses of two newly synthetized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. Their effects were compared with esmolol. Both compounds demonstrated significant bradycardic effects and induced blockade of the fast sodium current (INa) and potassium currents (Ito, IK1, IK). |