Publication details
Měření koncentrace metalothioneinu v nádorové tkáni a sliznici pacientů se spinocelulárním karcinomem hlavy a krku
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Dny prediktivní, diagnostické a experimentální onkologie, sborník abstrakt |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | metallothionein; MT concentration in tumor tissue; mucosa; muscle |
| Description | Metallothionein (MT) is an intracellular, low-molecular, cystein rich protein. MT is involved in zinc homeostasis, heavy metals metabolism and protection against oxidative stress. Recent studies have reported on the possible role of MT in carcinogenesis. MT overexpression was imunohistochemically confirmed in many different types of tumors. In most cases the high MT level was associated with worse prognosis and aggressive behavior of malignancy. Our study was aimed at MT concentration in full blood, tumor tissue and intact mucosa in patients with histologically verified head and neck tumors. MT level was measured by adsorptive transfer stripping technique (AdTS) with differential pulse voltametry (DPV) in blood and homogenized tumor tissue. Recieved results were correlated with clinical and pathological tumor characteristics (histology, staging, grading). |