Publication details

Neopterin and oxidative stress in patients with heart failure

Authors

TOMANDL Josef PAŘENICA Jiří TÁBORSKÁ Eva ŠPINAROVÁ Lenka ČERMÁKOVÁ Zdeňka ŠPINAR Jindřich

Year of publication 2007
Type Article in Proceedings
Conference Book of abstracts from the conference Synthetic and natural compounds in cancer therapy and prevention.
MU Faculty or unit

Faculty of Medicine

Citation
Field Biochemistry
Keywords heart failure; oxidative stress; neopterin; cell-mediated immunity
Description Recent data suggest among others that inflammation and oxidative stress may be associated with the development of heart failure. Neopterin is a sensitive marker for disease involving activated cell-mediated immune system in humans and besides induce oxidative stress in vitro. The aim of our study was to determine neopterin levels in patients with acute myocardial infarction (AMI) and chronic heart failure (CHF) and find a possible relationship with parameters of oxidative stress. The results of our study confirm an existence of T-lymphocyte activation, more in patients with ischemic origin of heart failure than cardiomyopathy. Moreover, cell-mediated activation of immune system might be independent on the time of progression of ischemic heart failure.
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