Publication details
Neopterin and oxidative stress in patients with heart failure
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | Book of abstracts from the conference Synthetic and natural compounds in cancer therapy and prevention. |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | heart failure; oxidative stress; neopterin; cell-mediated immunity |
| Description | Recent data suggest among others that inflammation and oxidative stress may be associated with the development of heart failure. Neopterin is a sensitive marker for disease involving activated cell-mediated immune system in humans and besides induce oxidative stress in vitro. The aim of our study was to determine neopterin levels in patients with acute myocardial infarction (AMI) and chronic heart failure (CHF) and find a possible relationship with parameters of oxidative stress. The results of our study confirm an existence of T-lymphocyte activation, more in patients with ischemic origin of heart failure than cardiomyopathy. Moreover, cell-mediated activation of immune system might be independent on the time of progression of ischemic heart failure. |
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