Publication details

Význam stanovení NtproBNP a big endotelinu pro diagnostiku chronického srdečního selhání u nemocných v pravidelném hemodialyzačním programu

Title in English The importance of determination of Nt-proBNP and big endothelin in diagnosing chronic heart failure in patients on regular haemodialysis treatment
Authors

LUDKA Ondřej ŠPINAR Jindřich VÍTOVCOVÁ Lenka SOBOTOVÁ Dorota ŠPINAROVÁ Lenka VÍTOVEC Jiří TOMANDL Josef

Year of publication 2007
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords congestive heart failure; hemodialysis; neurohumoral activation
Description We have followed 99 patients with end stage renal failure, treated by regular haemodialysis. Chronic renal failure is frequently accompanied by chronic heart failure (over 50 %), especially by heart failure with preserved ejection fraction. Patients treated by regular haemodialysis had a tendency to cardiomegaly (51 %), mild systolic dysfunction of the left ventricle (mean LVEF 53 %) and diastolic dysfunction (88 %) of the hypertrophic left ventricle. They had also activated endothelin and neurohumoral system. Only 3 % of the patients had normal values of Nt-proBNP and big endothelin. The plasma level of Nt-proBNP in haemodialysed patients correlated with cardiothoracic ratio and with ejection fraction. The plasma level of big endothelin correlated only with cardiothoracic ratio.
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