Publication details

Voltage homogenity over the membrane of cardiac cell with a transverse-axial tubular system

Authors

CHRISTÉ Georges PÁSEK Michal ŠIMURDA Jiří

Year of publication 2006
Type Article in Proceedings
Conference Analysis of Biomedical Signals and Images
MU Faculty or unit

Faculty of Medicine

Citation
Field Biophysics
Keywords cardiac myocytes; voltage homogenity; mathematical model
Description The surface membrane of cardiac ventricular myocytes has a complex system of invaginations known as the transverse-axial tubular system (TATS). In order to evaluate the functional importance of the TATS, one question to address is whether the surface and tubular transmembrane voltages differ at rest and during activity. We present here the theoretical background of the passive electrical properties of the interconnected ensemble formed with the surface membrane and the TATS membrane, the latter being simplified to a single compartment. We compare its behaviour with that of our model of ventricular cardiac myocyte with TATS. We conclude that both membrane compartments behave as a homogeneous electrical whole.
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