Publication details

Metalothionein jako prognostický marker nádorového onemocnění

Title in English METALLOTHIONEIN AS A PROGNOSTIC MARKER OF TUMOR DISEASE
Authors

ZELENÁ Jana POTĚŠIL David VACEK Jan HRADECKÝ Jan ADAM Vojtěch PRŮŠA Richard KIZEK René

Year of publication 2004
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Biochemistry
Keywords diagnostics; human tumors; metallothionein; overexpression; prognostic marker
Description Metallothionein is a low-molecular intracellular protein which can play an important role in heavy metal homeostasis in living organisms. Less is known about molecular mechanisms of MT expression. Metals probably participate in MT expression by binding to transcriptional factor MTF-1. Expression of human metallothioneins (MT-1a, MT-2a) can be induced by increasing amount of heavy metals, hormones, cytokines, and/or xenobiotics. Recent studies described the important relationship between MT and carcinogenesis, spontaneous mutagenesis and anti-cancer drugs. Overexpression of metallothioneins is studied as a new prognostic marker in a number of malignant and high grading tumors.

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