Publication details
Metody detekce alterovaných oblastí DNA z dat CGH arrays
| Title in English | Statistical approaches for identification of areas of DNA alteration analyzed by CGH arrays |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie, Supplementum |
| MU Faculty or unit | |
| Citation | |
| Field | Applied statistics, operation research |
| Keywords | array CGH statistical analysis breakpoint segmentation |
| Description | Nowadays, array CGH experiments became a powerful technique for analysing changes in DNA by comparing control DNA and DNA of interest. This is widely used for example in genome cancer studies. Analysis of the tumour genome instabilities and the search for tumour markers can be used for the tumour diagnostics (tumour classification, detection of the new clinical groups of tumours) or for the prediction of the response to therapy. The method produce huge amount of data and special statistic techniques for detecting of genomic changes are necessary. The purpose of this paper is to provide brief summary of existing statistical methods used in CGH array analysis and their software implementation. |