Publication details
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Angewandte Chemie International Edition |
| MU Faculty or unit | |
| Citation | |
| web | http://www3.interscience.wiley.com/cgi-bin/abstract/113394631/ABSTRACT?CRETRY=1&SRETRY=0 |
| Field | Biophysics |
| Keywords | conformation analysis; discodermolide; NMR spectroscopy; structure-activity relationships; tubulin |
| Description | Bound to have similarities: Although the overall shape of discodermolide bound to tubulin resembles the structure of the free ligand, the precise conformation and orientation of the lactone ring are different. A partially overlapping pharmacophore model supported by protein-mediated interligand NOE signals is proposed to explain the similar (but not fully equivalent) biological activity of discodermolide and epothilone A. |