Publication details
Distribution of heavy metals in liver foetus laboratory mice after their feed in pregnant females
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | sborník abstrakt 41.mezinárodního kongresu SAS a 43. Lojdova symposia |
| MU Faculty or unit | |
| Citation | |
| Keywords | heavy metals mouse liver light microscopy electron microscopy |
| Description | Already at the light microscopy level, all used heavy metals as dark granules of reaction product were observed in the liver of mothers and fetuses. In comparison with mother, fetal liver contained many more granules of reaction product in case of all followed metals. . At the level of electron microscopy we observed an interaction with biomembranes (all membranous structures were to be distinct even if the sections were not contrasted. On the basis of our results it is possible state, that heavy metals pass through the placenta in increased quantity and cumulate more in liver of fetus than of mother. Predilection seats of their cumulation is in the area of the central veins. Heavy metals are cumulated in hepatocytes and Kupffer cells. They „ impregnate" membranous structures, then penetrate biomembranes, and pass inwards the cells. Heavy metals cause disintegration of nuclear envelope, fission of nucleoli, condensation of chromatin. Further these metals implicate dilatation and fragmentation of rough endoplasmic reticulum and increased number of free ribosomes. Cumulation in lysosome with their following destruction and enlargment of mitochondria which, lose their inner organization are also caused by heavy metals influence. |