Publication details
The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí |
| MU Faculty or unit | |
| Citation | |
| Keywords | kidney rat amphotericin B deoxycholate amphotericin B colloidal dispersion |
| Description | Amphotericin B (AmB) is used in clinics despite its nephrotoxicity because it remains one of the most efficacious agents currently available for treatment of systemic fungal infections. Amphotericin B colloidal dispersion (ABCD) in addition to the conventional AmB deoxycholate is used in clinics. The goal of our study was to compare the morphology changes of a nephron in the rat after administration of ABCD and AmB. Preliminary clinic study did not show significant differences. Laboratory male rats (pathogen – free, source Anlab, Pratur, Czech Republic), 265-350 g of weight, were used as an experimental model. Two groups of animals were established: group 1 rats were treated with AmB deoxycholate ( Amphotericin B Squibb , Bristol-Myers Squibb,mg/kg of body weight daily for period of 14 days), in group 2 were animals treated with ABCD ( Amphocil, Torrex Pharma, 12 mg/kg of body weight daily for a period of 14 days). Rats were sacrificed and the kidneys were processed for light and elektron microscopy. It was executed also the morphometric study. |
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