Behavioural sensitization to methamphetamine affects expression of cannabinoid CB1 receptors in mouse midbrain.

• Authors: LANDA Leoš; JURAJDA Michal
• Year of publication: 2007
• Type: Article in Periodical
• Magazine / Source: Behavioural Pharmacology
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: behavioural sensitization; methamphetamine; PCR
• Description: The behavioural part of experiment showed stimulatory influence of methamphetamine (Met) after the acute administration and initiation of sensitization to Met after repeated treatment. Real-time PCR results showed increased CB1 mRNA expression after Met first dose followed by decrease in CB1 mRNA expression after the last dose of repeated treatment.

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