Publication details
Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Experimental Cell Research |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | MSF; NGAL; lipocalin; keratinocytes; fibroblasts; HaCat |
| Description | Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding. |
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