Effect of methamphetamine on cytochrome P450 activity.

• Authors: DOSTÁLEK Miroslav; JUŘICA Jan; PISTOVČÁKOVÁ Jana; HANESOVÁ Mariana; TOMANDL Josef; LINHART I.; ŠULCOVÁ Alexandra
• Year of publication: 2007
• Type: Article in Periodical
• Magazine / Source: Xenobiotica
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: Merhamphetamine; CYP450
• Description: The effect of methamphetamine pretreatment (10 mg kg(-1), intraperitoneally once daily for 6 days) on the activity of the P450 enzymes was assessed both in the rat isolated perfused liver and in vivo. Stimulatory effect on P4502C6 was recorded.

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