Publication details

Immunohistochemical evidence for down-regulation of cannabinoid CB1 receptors in the rat mesencephalon after self-administration of methamphetamine

Authors

SVÍŽENSKÁ Ivana DUBOVÝ Petr KLUSÁKOVÁ Ilona ŠULCOVÁ Alexandra KUČEROVÁ Jana

Year of publication 2007
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Citation
Description Image analysis disclosed the higher intensity of immunostaining for CB1 receptors in selected mesencephalic structures of the control animals than in methamphetamine treated rats. The down-regulation of CB1 receptors can decrease an inhibiting influence of GABA and thus the dopaminergic pathway activation by methamphetamine might be more intensive.
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