Immunohistochemical evidence for down-regulation of cannabinoid CB1 receptors in the rat mesencephalon after self-administration of methamphetamine

• Authors: SVÍŽENSKÁ Ivana; DUBOVÝ Petr; KLUSÁKOVÁ Ilona; ŠULCOVÁ Alexandra; KUČEROVÁ Jana
• Year of publication: 2007
• Type: Appeared in Conference without Proceedings
• MU Faculty or unit: Faculty of Medicine
• Description: Image analysis disclosed the higher intensity of immunostaining for CB1 receptors in selected mesencephalic structures of the control animals than in methamphetamine treated rats. The down-regulation of CB1 receptors can decrease an inhibiting influence of GABA and thus the dopaminergic pathway activation by methamphetamine might be more intensive.

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