Stanovení exprese genu pro kanabinoidní CB1 receptor pomocí real time PCR v myším mezencefalu po senzitizaci metamfetaminem

• Title in English: Assessment of gene expression for cannabinoid CB1 receptor using real time PCR in mice mesencephalon after methamphetamine sensitization
• Authors: LANDA Leoš; JURAJDA Michal
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Psychiatrie
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: behavioural sensitization; methamphetamine; CB1 receptor; real time PCR
• Description: Real-time PCR results showed increased CB1 mRNA expression after Met first dose followed by decrease in CB1 mRNA expression after the last dose of the repeated treatment. This suggests that methamphetamine administration can elicit changes on the genomic level at least in the mouse mesencephalon neurons, both, in animals after acute drug administration and sensitised animals.

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