Publication details
fMRI evaluation of hemispheric language dominance using various methods of laterality index calculation.
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Experimental Brain Research |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Language; Laterality index; Temporal lobe epilepsy; fMRI; Wada test |
| Description | There is extensive variance in the Laterality index (LI) calculation across the studies, and the optimal calculation method remains unclear. We attempted to calculate the LI in different ways in the same subjects, in order to find the LI calculation method with the highest correlation to the Wada test. Regions of interest (ROIs), with a known association with language function were defined. First, the LIs were calculated from the ROIs using a previously reported method (simple suprathreshold count). Next, we used several new methods of LI calculation (t-weighting of voxels, methods independent of the choice of the statistical threshold, etc.) The most significant correlation with Wada was proven in the LIs that were evaluated from Broca's area. However, the new LI calculation methods used in the present study did not produce a statistically significant benefit in comparison to previously reported methods. |
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