Publication details
CD127neg and FoxP3+ Expression on CD25+CD4+ T Regulatory Cells upon Specific Diabetogeneic Stimulation in High-risk Relatives of Type 1 Diabetes Mellitus Patients
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | SCANDINAVIAN JOURNAL OF IMMUNOLOGY |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.blackwell-synergy.com/action/showFullText?submitFullText=Full+Text+HTML&doi=10.1111%2Fj.1365-3083.2008.02074.x |
| Field | Immunology |
| Keywords | Regulatory T Cells; Type 1 Diabetes Mellitus; Relatives |
| Description | Abnormalities in CD4+CD25+ regulatory T cells (Treg) may contribute to type 1 diabetes (T1D) development. First-degree relatives of T1D patients are at increased risk especially when they carry certain HLA II haplotypes. Using two novel markers of CD4+CD25+ Treg (CD127neg and FoxP3+ respectively), we evaluated number and function of Treg after specific stimulation with diabetogeneic autoantigens in 11 high-risk relatives of T1D patients and 14 age-matched healthy controls. High-risk relatives of T1D patients had significantly lower pre and post-stimulatory number of CD127neg Treg than that of healthy controls. Labelling Treg with FoxP3+ demonstrated similar trend but did not reach statistical significance. The defective function of Treg was performed by significantly higher activation of diabetogeneic T cells in high-risk relatives of T1D patients compared to healthy controls. |