Publication details
Je humorální aktivace u srdečního selhání ovlivněna genetickou predispozicí?
| Title in English | Is the humoral acrtivation in heart failure influenced by genetic predisposition? |
|---|---|
| Authors | |
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Cor et Vasa |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | humoral activation |
| Description | Aim of study: To document an association between the plasma levels of big endothelin and endothelin-1, clinical parameters and the two most frequent polymorphisms (-3A/-4A and G8002A) of the endothelin-1-encoding gene on the one hand and the plasma levels of TNF-a, clinical parameters and the gene polymorphisms of TNF-a -308 A/G, -238 A/G, TNF-b Ncol, and 3 TACE (tumor necrosis factor-a-converting enzyme) in patients with chronic heart failure (HF). Conclusion: The hypothesis is suggested that a crucial role in endothelin and TNF-a production in heart failure is not played by the patient s genetic make-up but, rather, by their hemodynamic status due to the underlying clinical disease. |
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