Publication details

Imunohistochemická detekce exprese genu p53 a p21 v buňkách maligního melanomu uvey.

Title in English Immunohistochemical detection of the gene p53 and p21 expression in cells of the malignanat melanoma of the uvea.
Authors

TOKOŠOVÁ Elena HERMANOVÁ Markéta UHMANNOVÁ Radoslava ŠMARDOVÁ Jana HLINOMAZOVÁ Zuzana

Year of publication 2008
Type Article in Periodical
Magazine / Source Česká a Slovenská oftalmologie
MU Faculty or unit

Faculty of Medicine

Citation
Field ORL, ophthalmology, stomatology
Keywords malignant melanoma of the uvea; immunohistochemical detection; tumor suppressor p53; p21
Description Expression of both p53 and p21 was immunohistochemically revealed in 14,3 % of malignant melanomas of uvea. Based on the results, the stabilizing mutations of p53 are rare in the melanomas of uvea and the found expression of p53 seems to be a result of wild-type p53 expression because of the ability to induce the expression of p21.

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