Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications

• Title in English: Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications.
• Authors: JUŘICA Jan; ŽOURKOVÁ Alexandra; FLODROVÁ Eva; MCCASKEY HADAŠOVÁ Eva
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague.
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: CYP2D6; phenotype; psychiatry
• Description: Possibilities of CYP2D6 phenotype and genotype determination in psychiatric patients were discussed. Then, the the influence of phenotype of CYP2D6 on clinical response was evaluated (patients with anxiety disorder on paroxetine treatment; n=16). Influence of phenotype on the adverse effects occurence was evaluated as well (including sexual dysfunctions) in the long term paroxetine treatment(patients treated with paroxetine for more than 3 months; n=50).

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