Publication details

Significance of AMP-activated protein kinase for the effect of leptin

Authors

JÍLKOVÁ Zuzana KŮS Vladimír MEDŘÍKOVÁ Daša JANOVSKÁ Petra PAVELKA Stanislav KOPECKÝ Jan

Year of publication 2008
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Science

Citation
Field Endocrinology, diabetology, metabolism, nutrition
Keywords hormone; leptin; protein kinase
Description The significance of AMP-activated protein kinase (AMPK) for the leptin effect in post-weaning mice was investigated using alpha2 AMPK KO mice. Our results indicate that absence of alpha2 AMPK subunit leads to disruption of signaling pathway for leptin suggesting that alpha2 AMPK subunit is necessary for the effect of leptin.
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