Publication details
Burkittův lymfom: přehled patofyziologie, diagnostiky a terapie
| Title in English | Burkitt's lymphoma: pathophysiology, diagnostics and treatment |
|---|---|
| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Transfúze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | Burkitts lymphoma; Epstein-Barr virus; molecular biology; c-myc; tumor lysis syndrom; chemotherapy |
| Description | Burkitts lymphoma is a highly aggressive mature B-cell malignancy with a characteristic chromosomal translocation of c-myc proto-oncogene. Clinically, it manifests mostly by an extranodal involvement, affection the gastrointestinal system and usually by developing of a big tumor mass. Burkitts lymphoma requires an early medical treatment that is nowadays based on intensive combined cycles of chemotherapeutic agents. A part of the therapy includes a prophylaxis of the affection of central nervous system by tumor cells, where high-dose methotrexate, cytosinarabinosid and intrathecal therapy is used. With respect to regular CD20 positivity in cancer cells, the best curative outcome is achieved by a combination of cytostatic agents therapy with a monoclonal antibody therapy rituximab. Burkitts lymphoma is nowadays ranked among potentially curable diseases. |