Publication details
C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Proceedings |
| Conference | XXIII International Conference on Magnetic Resonance in Biological Systems |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Keywords | NMR; nucleic acids;RNA;dynamics |
| Description | NMR relaxation experiments provide a way of monitoring molecular dynamics with atomic resolution. However, the measurement of 13C relaxation rates and their interpretation faces serious challenges. We have modified the Model-Free procedure to explicitly take into account asymmetric character of the carbon chemical shielding tensors and the effect of neighboring nuclei. The extended version of the Model-Free analysis generally produces more realistic values of the order parameter. |
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