Publication details
PROGRESE AUTONOMNÍCH DYSFUNKCÍ V PRŮBĚHU PARKINSONOVY NEMOCI
| Title in English | PROGRESION OF AUTONOMIC DYSFUNCTION PROGRESSION IN THE COURSE OF PARKINSONS DISEASE |
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| Authors | |
| Year of publication | 2008 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Exact quantitative evaluation method of autonomic dysfunction in Parkinsons disease (PD) for everyday clinical use has not been developed yet. The aim of this study was to evaluate autonomic cardiovascular regulation in mild and advanced stages of PD with the use of heart rate variability (HRV) examination. 25 patients entered the study and absolved short term HRV examination in supine position with metronome paced breathing f = 0.33 Hz. Following parameters of power spectral analysis were evaluated: Total Power (TP; ms2), Low Frequency Power (0.04-0.14 Hz; Power LF; ms2), High Frequency Power (0.15-0.4 Hz; Power HF; ms2) and Ratio Power LF / Power HF (LF/HF). The results show statistically significant decrease of TP (438 vs. 123 ms2), Power LF (132 vs. 40 ms2) and Power HF (251 vs. 47 ms2) in the group of patients with higher mean H&Y (1.3 vs. 2.3; T test). The change of LF/HF was not statistically significant. The short term examination of heart rate variability fulfils criteria for test objectivity, reproducibility, reliability and validity. We proved higher impairment of autonomic cardiovascular regulation in the group of PD patients with advanced PD (H&Y = 2.3) than in mild PD (H&Y = 1.3). Short term HRV examination is also sensitive enough to be used for comparison of difference of autonomic dysfunction corresponding to the change of 1 grade in H&Y score. |
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