Publication details

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vitro

Authors

ANDERSSON Emma R. PRAKASH Nilima ČAJÁNEK Lukáš MININA Eleonora BRYJA Vítězslav BRYJOVÁ Lenka YAMAGUCHI Terry P. HALL Anita C. WURST Wolfgang ARENAS Ernest

Year of publication 2008
Type Article in Periodical
Magazine / Source PloS ONE
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Wnt5a deficient mouse, ventral midbrain, planar cell polarity
Description Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves multiple functions during development. We hereby report a Wnt5a regulation of Wnt/PCP signaling in the DA lineage and provide evidence for multiple functions of Wnt5a in the VM in vivo, including the regulation of VM morphogenesis, DA progenitor cell division, and differentiation of NR4A2+ DA precursors.

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