Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vitro

• Authors: ANDERSSON Emma R.; PRAKASH Nilima; ČAJÁNEK Lukáš; MININA Eleonora; BRYJA Vítězslav; BRYJOVÁ Lenka; YAMAGUCHI Terry P.; HALL Anita C.; WURST Wolfgang; ARENAS Ernest
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: PloS ONE
• MU Faculty or unit: Faculty of Science
• Field: Genetics and molecular biology
• Keywords: Wnt5a deficient mouse, ventral midbrain, planar cell polarity
• Description: Wnt5a is a morphogen that activates the Wnt/planar cell polarity (PCP) pathway and serves multiple functions during development. We hereby report a Wnt5a regulation of Wnt/PCP signaling in the DA lineage and provide evidence for multiple functions of Wnt5a in the VM in vivo, including the regulation of VM morphogenesis, DA progenitor cell division, and differentiation of NR4A2+ DA precursors.