Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin

• Authors: BRYJA Vítězslav; PACHERNÍK Jiří; VONDRÁČEK Jan; SOUČEK Karel; ČAJÁNEK Lukáš; HORVÁTH Viktor; HOLUBCOVÁ Zuzana; DVOŘÁK Petr; HAMPL Aleš
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Cell Proliferation
• MU Faculty or unit: Faculty of Medicine
• Field: Genetics and molecular biology
• Keywords: G1/S transition; cyclin D; embryonic cells differentiation
• Description: Using P19 embryonal carcinoma cells, which we induces to differentiate either to neural or endodermal lineage, we demonstrate that composition of crucial G1/S transition regulating complexes does not reflect only proliferation parameters. Cyclin D-Cdk4/Cdk6-p27 complexes dramatically change depending on the differentiation pathways, which suggests the these complexes also regulate differentiation.