Publication details

Autologous Dendritic Cell Vaccination in Multiple Myeloma Patients – A First Clinical Results and Safety Evaluation in a Phase II Clinical Trial

Authors

ZAHRADOVÁ Lenka OČADLÍKOVÁ Darina KOVÁŘOVÁ Lucie SMEJKALOVÁ Jana POUR Luděk PENKA Miroslav MICHÁLEK Jaroslav HÁJEK Roman

Year of publication 2008
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Six patients with multiple myeloma not requiring systemic therapy was enrolled to the study. Patients received 6 doses of dendritic cells (DCs)loaded with autologous Id-protein every 4 weeks. The vaccine was administred subcutaneously. Autologous mature DCs derived from peripherial blood monocytes were prepared in vitro and loaded with Id-protein under the GMP conditions. A clinical response was evaluated by measuring the monoclonal immunoglobulin levels in peripheral blood. An immune response was monitored by flow cytometry every 4 weeks as well as the production of interferon gamma (evaluated by Elispot) by myeloma-reactive T lymphocytes. A delayed type hypersensitivity test was performed every 3 months. Vaccination was well tolerated with only mild fever up to 37,5st.C in 1 patient, no other grade II-IV toxicities were observed. A local reaction (erythema or induration) was observed in all patients and disappeared in 2-6 days. The immune response to the vaccine was noticed in 3 of 4 patients who completed the vaccination and these 3 patients remained in stable disease while one evaluable patient with no immune response revealed progressive disease (the follow-up of these patients is 19-20 months, median 20 months). The trial is ongoing and a total number of 12 patients is planned to be enrolled. Vaccination with Id-protein loaded autologous DCs is a safe therapeutic strategy with no significant side effects. The final evaluation of clinical response needs to be performed in a longer follow-up.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info