Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage

• Authors: KREJČÍ Pavel; SALAZAR Lisa; KASHIWADA Tamara A.; CHLEBOVÁ Katarína; SALAŠOVÁ Alena; THOMPSON Leslie Michels; BRYJA Vítězslav; KOZUBÍK Alois; WILCOX William R.
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: PLoS ONE.
• MU Faculty or unit: Faculty of Science
• Field: Genetics and molecular biology
• Keywords: FGFR3; STAT1; activation; skeletal dysplasia
• Description: Article analyses activation of STAT1 by the six different FGFR3 mutants associated with skeletal dysplasia. We report that only the K650E and K650M mutants activate STAT1. As these mutants represent only a mionority of patients suffering from FGFR3-related skeletal dysplasia, it appears that STAT1 might not be the major intermediate of FGFR3 signaling in cartilage.

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