Publication details
Polymorfizmus genu pro OPRM1 a schizofrenie: nové výsledky asociační studie
| Title in English | OPRM1 gene polymorphism and schizophrenia: new results of association study |
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| Authors | |
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | schizophrenia association study polymorphism OPRM1 DNA gene |
| Description | Etiology of schizophrenia is associated with disruptions in neural development. Neurodevelopment theory is supported by quite strong genetic evidence. In our study, we studied the relationship between functional A118G polymorphism of OPRM1 gene and schizophrenia. The results showed statistically significant difference of allelic and genotypic frequencies between control and schizophrenic males. According recent knowledge, we suppose that OPRM1 gene polymorphism can influence myelinization of CNS neurons through regulation of expression of OPRM1 receptors on oligodendrocytes. Process of myelinization of CNS neurons seems to be an important factor of pathogenesis of schizophrenia. |
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