Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma

• Authors: LUDWIG Heinz; HÁJEK Roman; TÓTHOVÁ Elena; DRACH Johannes; ADAM Zdeněk; LABAR Boris; EGYED Miklós; ŠPIČKA Ivan; GISSLINGER Heinz; GREIL Richard; KUHN Ingrid; ZOJER Niklas; HINKE Axel
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: Blood
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: multiple myeloma; thalidomide; dexamethasone; melphalane; prednisone
• Description: We compared thalidomide-dexamethasone with melphalan-prednisolone in 289 elderly patients with multiple myeloma. This is the first trial to compare TD with MP in elderly patients. Results in the TD group showed a significantly higher rate of very good responses (CR and VGPR) and significantly shorter time to response with no difference in time to progression and in progression-free survival.

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