Publication details

YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS

Authors

HAVELKOVÁ Marie UNGER Eberhard

Year of publication 2009
Type Article in Proceedings
Conference 37th Annual Conference on Yeasts.
MU Faculty or unit

Faculty of Education

Citation
Field Genetics and molecular biology
Keywords Yeast Cell - cytostatics - cell cycle - mitosis - nuclear division - microtubular cytoskeleton - actin filaments - calmodulin - cell senescence
Description Three selected yeast strains of Yarrowia lipolytica species were used as modelling objects to test 62 chemical substances considered to be potentional cytostatics. In the cells following phenomena were observed and analysed: 1/ process of cell cycle, 2/ process of mitosis, 3/ morphology of nucleus, formation of polynuclear forms, 3/ amount of DNA in nucleus, polyploid nuclei formation, 4/ localization, morphology of microtubular cytoskeleton, 5/ amount and localization of actin microfilaments, 6/ presence, amount and localization of calmodulin. Six of all analysed substances were found to be appropriate (as cytostatics) and were suggested for a further detailed analysis.
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