Piracetam potencuje psychostimulační účinky metamfetaminu a extáze u myší v testu otevřeného pole

• Title in English: Piracetam potentiates psychostimulant effects of metamphetamine and MDMA in the open-field test
• Authors: ŠLAIS Karel; VRŠKOVÁ Dagmar; ŠULCOVÁ Alexandra
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: Psychiatrie
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: piracetam; methamphetamine; psychostimualnt drugs; preclinical experiments
• Description: Many press and internet reports mention abuse of nootropic drug piracetam (PIR) in combination with psychostimulants methamphetamine (METH) or MDMA. Acute effects of drugs given to mice intraperitoneally (METH 2.5 mg/kg; MDMA 2.5 mg/kg; PIR 300 mg/kg; PIR+MET; PIR+MDMA) were tested in the open field test.PIR given alone caused no significant changes in mouse behaviour. Significant stimulatory influence of METH and MDMA increased mouse locomotion in the open field significantly more markedly after the combined administration of PIR+METH or PIR+MDMA.

Related projects

• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.