Publication details

Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Authors

GUZI Timothy PARUCH Kamil DWYER Michael LABROLI Marc KEERTIKAR Kartik

Year of publication 2007
Type Patent
MU Faculty or unit

Faculty of Science

Publisher United States Patent and Trademark Office
State United States of America
Patent's number US 2007/0281951 A1
Description The title compds. [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I, alone or in combination with other therapeutic agent, is claimed.

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