Publication details
Imidazopyrazines as protein kinase inhibitors
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectual Property Organization |
| State | United States of America |
| Patent's number | WO 2007/058942 A2 |
| Description | The title compds. I [R = H, cycloalkyl, heteroaryl, etc.; R1 = H, halo, aryl, etc.; R2 = H, halo, aryl, etc.; R3 = H, alkyl, cycloalkyl, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. A multi-step synthesis of II, starting from 2,3-dichloropyrazine, is given. Compds. I were tested against various kinases (data given for representative compds. I). This invention relates also to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. |