Publication details

Imidazopyrazines as protein kinase inhibitors

Authors

ZHAO Lianyun CURRAN Patrick BELANGER David HAMANN Blake REDDY Panduranga PARUCH Kamil GUZI Timothy DWYER Michael SIDDIQUI Arshad TADIKONDA Praveen

Year of publication 2007
Type Patent
MU Faculty or unit

Faculty of Science

Publisher World Intellectual Property Organization
State United States of America
Patent's number WO 2007/058942 A2
Description The title compds. I [R = H, cycloalkyl, heteroaryl, etc.; R1 = H, halo, aryl, etc.; R2 = H, halo, aryl, etc.; R3 = H, alkyl, cycloalkyl, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. A multi-step synthesis of II, starting from 2,3-dichloropyrazine, is given. Compds. I were tested against various kinases (data given for representative compds. I). This invention relates also to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns.

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