Publication details
Pyrazolopyrimidines as protein kinase inhibitors
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | United States Patent and Trademark Office |
| State | United States of America |
| Patent's number | US 2007/0082901 A1 |
| Description | The title compds. I [X = NH, O, S; Ar = (un)substituted (hetero)aryl, fused (hetero)aryl; R1 = H, CF3, CN, etc.; R2 = H, CF3, CN, etc,; R3 = H, alkyl, alkenyl, etc.; R4 = H, OH, (un)substituted NH2], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a 3-step synthesis of I [R1-R4 = H; X = O; Ar = 5-indolyl], starting from 1,3-dimethyluracil and 3-aminopyrazole, was given. This invention also relates to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. |