Publication details
Methods for inhibiting protein kinases
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | United States Patent and Trademark Office |
| State | United States of America |
| Patent's number | US 2007/0082900 A1 |
| Description | The invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compds. of formula I, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with protein kinases using such compds. Compds. of formula I wherein R is H, alkyl, alkenyl, alkynyl, aralkyl, arylalkenyl, cycloalkyl, cycloalkylalkyl, alkenylalkyl, etc.; R2 is H, alkyl, alkenyl, alkynyl, CF3, heterocyclyl(alkyl), halo, haloalkyl, (hetero)aryl(alkyl), etc.; R3 is H, halo, NH2 and derivs., OH and derivs., SH and derivs., CONH2 and derivs., alkyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R4 is H and alkyl; and their pharmaceutically acceptable salts, solvates, esters and prodrugs thereof, are claimed. Example compd. II was prepd. by a multistep procedure (procedure given). All the invention compds. were evaluated for their protein kinase inhibitory activity. |