Publication details
Pyrazolopyrimidines as protein kinase inhibitors
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectual Property Organization |
| State | United States of America |
| Patent's number | WO 2007/041712 A1 |
| Description | The title compds. I [R2 = halo, CF3, CN, etc.; R3 = H, (un)substituted NH2, OH, etc.; R4 = CF3, CN, (un)substituted NH2, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a multi-step synthesis of II, starting from N-tert-butoxycarbonylpiperidine-3-carboxylic acid, was given. II showed IC50 of 86 nM against CHK1 and IC50 of 989 nM against CDK2/cyclin A. This invention also relates to pharmaceutical compns. including one or more compds. I, methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. |