Publication details
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | United States Patent and Trademark Office |
| State | United States of America |
| Patent's number | US 2007/0072882 A1 |
| Description | Title compds. I [R = (un)substituted heteroaryl; R2 = alkyl, alkynyl, CF3, aryl, etc.; R3 = H, halo, alkyl, heteroaryl, etc.; R4 = H, halo or alkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as inhibitors of cyclin dependent kinases (CDKs). Thus, e.g., II was prepd. by substitution of III (prepn. given) with 3-aminoazetidine. In in vitro kinase activity assays, select compds. of the invention demonstrated IC50 values ranging from 0.05 - 49 (.mu.M). Further disclosed are pharmaceutical compns. contg. one or more of I, methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. |