Publication details
Aktivace autologních transplantátů hematopoetických kmenových buněk interleukinem 2
| Title in English | Activation of autologous hematopoietic stem cell transplants with interleukin-2 |
|---|---|
| Authors | |
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Časopis lékařů českých |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | interleukin-2; autologous transplantation; stem cell |
| Description | Recent findings of the role of the immunity in eradication of residual tumour tissue after autologous transplantation rejection leading to extensive studies on T-cell mediated specific antitumor effects or nonspecific NL-cell mediated anticancer effects. We have evaluated on the methods of adoptive cell therapy IL-2 activation of autologous graft in the preclinical conditions. In laboratory conditions we have manipulated with autologous grafts form patients suffering with chronic myelocytic leukemia and patients suffering with multiple myeloma.We have proved the possibility to use IL-2 activated autologous graft in the clinical conditions. Based on our preclinical results experimental clinical trials have been initiated in patients suffering from chronic myelocytic leukemia and multiple myeloma. |