Publication details

Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds

Authors

MALLAMS Alan MADISON Vincent PARUCH Kamil

Year of publication 2007
Type Patent
MU Faculty or unit

Faculty of Science

Publisher World Intellectula Property Organization
State United States of America
Patent's number WO 2007/032936 A2
Description The invention provides a class of bicyclic heterocyclic compds. of formulas I, II, and III as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Compds. of formulas I, II, and III wherein X is C or N; Y is CH, NH2, and CH2NH2; R1 is H, halo, NH2, (un)substituted alkyl, alkenyl, (hetero)aryl, CF3, etc.; R2 is H, halo, NH2 and derivs., CO2H and derivs., CONH2 and derivs., alkyl, alkenyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R3 is halo, CN, amino, alkylamino, cycloalkylamino, arylakylamino, hydroxyalkylamino, etc.; R4 is H, halo, CN and alkyl; are claimed. Example compd. IV was prepd. by cyanation of 5-bromo-6-phenyl-8-(pyridin-3-ylmethylamino)imidazo[1,5-a]pyrazine with zinc cyanide. All the invention compds. were evaluated for their CDK inhibitory activity.

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