Publication details
Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | US Patent Office |
| State | United States of America |
| Patent's number | US 2006128725 A1 |
| Description | The title compds. are substituted pyrazolo[1,5-a]pyrimidines [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed. |