Publication details
Pyrazolotriazines as Kinase Inhibitors
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | United States Patent and Trademark Office |
| State | United States of America |
| Patent's number | US 2005/187219 A1 |
| Description | In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compds. (I, variables defined below) as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the kinases using such compds. or pharmaceutical compns. For I, R1 is H, optionally substituted alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR6R7, cycloalkyl and cycloalkylalkyl; R2 is alkyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, OR7, SR7, hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or alkylene-N(R8R9) [where R8 and R9 represent H or alkyl, or R8 and R9 taken together with the nitrogen in -N(R8R9) form a five- to seven-membered heterocycle]; R3 is -NR4R5, substituted heterocycle, H, alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl; R4 is optionally substituted alkyl, cycloalkyl or heterocyclyl; R5 is H, alkyl, aryl, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl or heteroarylalkyl; R6 is H, alkyl or aryl; R7 is H or alkyl. |