Publication details

Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

Authors

GUZI Timothy PARUCH Kamil DWYER Michael DOLL Ronald GIRIJAVALLABHAN Viyyoor MALLAMS Alan ALVAREZ Carmen KEERTIKAR Kartik RIVERA Jocelyn CHAN Tin-Yau MADISON Vincent FISCHMANN Thierry DILLARD Lawrence TRAN Vinh ZHEN Min JAMES Ray PARK Haengsoon PARADKAR Vidyadhar HOBBS Douglas

Year of publication 2004
Type Patent
MU Faculty or unit

Faculty of Science

Publisher United States Patent and Trademark Office
State United States of America
Patent's number US 2004/209878 A1
Description The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.

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