Publication details
Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | United States Patent and Trademark Office |
| State | United States of America |
| Patent's number | US 2004/209878 A1 |
| Description | The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed. |