Publication details

Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors

Authors

DWYER Michael GUZI Timothy PARUCH Kamil DOLL Ronald KEERTIKAR Kartik GIRIJAVALLABHAN Viyyoor

Year of publication 2004
Type Patent
MU Faculty or unit

Faculty of Science

Publisher World Intellectual Property Organization
State United States of America
Patent's number WO 2004/026872 A1
Description In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compds. I [R = (un)substiuted-alkyl, -aryl, -heteroaryl, -heteroarylalkyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -alkenyl, -alkynyl, -aryl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, -aryl, -heteroaryl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 7-amino-5-phenylpyrazolo[1,5-a]pyridine (prepn. given) with 3-formylpyridine. I possessed excellent CDK inhibitory properties as demonstrated by the IC50 value for III of 0.078 .mu.M in inhibition of CDK2.

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