Publication details
Imidazopyridines as Cyclin Dependent Kinase Inhibitors
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectual Property Organization |
| State | United States of America |
| Patent's number | WO 2004/026867 A2 |
| Description | In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compds. I [R = (un)substituted-alkyl, -aryl, -heteroaryl, -heterocyclyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -aryl, arylalkyl, alkenyl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was made by condensation of 8-amino-3-bromo-6-phenylimidazopyridine (prepn. given) with 5-formylpyrimidine. In inhibition assays with CDK2, I possessed excellent inhibitory properties, e.g., II possessed an IC50 value of 0.12 uM. |