Publication details
Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectual Property Organization |
| State | United States of America |
| Patent's number | WO 2004/026229 A2 |
| Description | In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compds. I [R = (un)substituted aryl; R2 = halo, CN, (un)substituted alkyl, etc.; R3 = H, halo, (un)substituted-alkyl, -alkynyl, -aryl, etc.; R4 = H, halo or alkyl] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by substitution of 3-bromo-7-chloro-5-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine (prepn. given) with aniline. I exhibit excellent CDK inhibitory properties as demonstrated by II which possessed a IC50 value of 0.51 uM in kinase activity assays. |