CHROMATIN ASSOCITED HMGB1 PROTEIN IS INVOLVED IN REGULATION OF TELOMERE LENGTHS IN PLANTS

• Authors: PROCHÁZKOVÁ SCHRUMPFOVÁ Petra; GRASSER Klaus; FAJKUS Jiří
• Year of publication: 2009
• Type: Conference abstract
• MU Faculty or unit: Faculty of Science
• Description: High Mobility Group (HMG) proteins type B bind local DNA structures, promote DNA bending and interact with factors of the transcription, repair and recombination machineries. Arabidopsis thaliana genome encodes 7 HMGB proteins which differ in structure, expression pattern and DNA-binding properties. We observe that HMGB1 takes part in telomere maintenance. Plants lacking HMGB1 display telomere shortening and, consistently, overexpression of HMGB1 leads to telomere elongation.

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