Experimental models of peripheral neuropathic pain based on traumatic nerve injuries. An anatomical perspective

• Authors: KLUSÁKOVÁ Ilona; DUBOVÝ Petr
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: Annals of Anatomy-Anatomischer Anzeiger
• MU Faculty or unit: Faculty of Medicine
• Field: Neurology, neurosurgery, neurosciences
• Keywords: neuropathic pain; animals models; nerve injury
• Description: Peripheral neuropathic pain (PNP) frequently occurs as a consequence of nerve injury. Progress in our knowledge of PNP induction mechanisms depends upon the utilization of appropriate experimental models in rodents based on various types of peripheral nerve lesions. In this review, we draw attention to current knowledge on basic cellular and molecular events in various experimental models used to induce the PNP symptoms.

Related projects

• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
• Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury