Publication details
Klonální evoluce u chronické lymfocytární leukemie
| Title in English | Clonal evolution in chronic lymphocytic leukemia |
|---|---|
| Authors | |
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Časopis lékařů českých |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | chronic lymphocytic leukemia; chromosomal aberations; clonal evolution |
| Description | Chromosomal aberrations have important prognostic significance in patients with chronic lymphocytic leukemia. Aberrations detected by fluorescence in situ hybridization define specific subgroups that differ in the overall survival and the time from diagnosis to first treatment. Patients with deletion 17p appear resistant to standard chemotherapy regimens and detection of this cytogenetic abnormality may influence therapeutic decisions. Because additional genetic defedts (clonal evolution) may be acquired during the course of the disease, cytogenetic analysis is recommended not only ad diagnosis, but prior every line of the treatment. |