Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells

• Authors: NAVRÁTILOVÁ Jarmila; JUNGOVÁ Pavla; VAŇHARA Petr; PREISLER Jan; KANICKÝ Viktor; ŠMARDA Jan
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: International Journal of Molecular Medicine
• MU Faculty or unit: Faculty of Science
• Field: Oncology and hematology
• Keywords: disulfiram; copper; myeloid leukemia; cell density; inoculum effect; SALD ICP MS
• Description: In this study, we report the cell density-dependent induction of apoptosis of human acute myeloid leukemia U937 and ML-1 cells by disulfiram (DSF), the dithiocarbamate drug recently proposed for treatment of human cancers. This effect is dependent on uptake of extracellular copper and its intracellular accumulation.

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